Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses.
Girkontaite I, Missy K, Sakk V, Harenberg A, Tedford K, Pötzel T, Pfeffer K, Fischer KD.
Abteilung Physiologische Chemie, Universität Ulm, Albert-Einstein-Allee 11, D-89069 Ulm, Germany.
Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the G alpha(13) subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates G alpha(12) and G alpha(13). Lsc is expressed primarily in the hematopoietic system and links the activation of G alpha(12) and G alpha(13)-coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the generation of immune responses. Although Lsc-deficient lymphocytes show reduced basal motility, MZB cells show enhanced migration after serum activation. Thus, Lsc is a critical regulator of MZB cells and immune functions.
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PMID: 11526402 [PubMed - indexed for MEDLINE]