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1.

441
Accesses

Research article   Open Access Highly Accessed

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

Sanjit K Roy, Rakesh K Srivastava, Sharmila Shankar Journal of Molecular Signaling 2010, 5:10 (19 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

331
Accesses

Review   Open Access

NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significance

Chris YK Cheung, Ben CB Ko Journal of Molecular Signaling 2013, 8:5 (23 April 2013)

Abstract | Full text | PDF | PubMed

3.

317
Accesses

Research article   Open Access Highly Accessed

The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition

Su-Ni Tang, Chandan Singh, Dara Nall, Daniel Meeker, Sharmila Shankar, Rakesh K Srivastava Journal of Molecular Signaling 2010, 5:14 (18 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

312
Accesses

Research article   Open Access

Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin

Noriko Yokoyama, Nelli G Markova, Hsien-yu Wang, Craig C Malbon Journal of Molecular Signaling 2012, 7:8 (29 June 2012)

Abstract | Full text | PDF | ePUB | PubMed

5.

298
Accesses

Review   Open Access

Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine

Vasileios A Stamelos, Charles W Redman, Alan Richardson Journal of Molecular Signaling 2012, 7:12 (16 August 2012)

Abstract | Full text | PDF | ePUB | PubMed

6.

296
Accesses

Review   Open Access Highly Accessed

Signaling in colon cancer stem cells

Sanchita Roy, Adhip PN Majumdar Journal of Molecular Signaling 2012, 7:11 (6 August 2012)

Abstract | Full text | PDF | ePUB | PubMed

7.

242
Accesses

Research article   Open Access Highly Accessed

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1

Yongxian Zhuang, W Keith Miskimins Journal of Molecular Signaling 2008, 3:18 (1 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

240
Accesses

Research article   Open Access Highly Accessed

Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

Jyoti Nautiyal, Shailender S Kanwar, Yingjie Yu, Adhip PN Majumdar Journal of Molecular Signaling 2011, 6:7 (20 July 2011)

Abstract | Full text | PDF | PubMed

9.

240
Accesses

Research article   Open Access

Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas

Susanne Fransson, Per Kogner, Tommy Martinsson, Katarina Ejeskär Journal of Molecular Signaling 2013, 8:4 (18 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

228
Accesses

Research article   Open Access

Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells

Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Jaleel Kizhakkayil, Shahanas Chathoth, Mahendra Patel, Sehamuddin Galadari Journal of Molecular Signaling 2013, 8:2 (27 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

11.

226
Accesses

Research article   Open Access Highly Accessed

AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

Gilles M Leclerc, Guy J Leclerc, Guilian Fu, Julio C Barredo Journal of Molecular Signaling 2010, 5:15 (23 September 2010)

Abstract | Full text | PDF | PubMed

12.

223
Accesses

Research article   Open Access

Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling

Benjamin J Ritchie, William C Smolski, Ellyn R Montgomery, Elizabeth S Fisher, Tina Y Choi, Calla M Olson, Lori A Foster, Thomas E Meigs Journal of Molecular Signaling 2013, 8:3 (25 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

218
Accesses

Research article   Open Access Highly Accessed

Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells

Shingo Tanaka, Kumiko Terada, Tsutomu Nohno Journal of Molecular Signaling 2011, 6:12 (5 October 2011)

Abstract | Full text | PDF | PubMed

14.

213
Accesses

Research article   Open Access Highly Accessed

Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis

Sharmila Shankar, Qinghe Chen, Krishna Sarva, Imtiaz Siddiqui, Rakesh K Srivastava Journal of Molecular Signaling 2007, 2:10 (4 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

204
Accesses

Review   Open Access Highly Accessed

Gadd45 in stress signaling

Dan A Liebermann, Barbara Hoffman Journal of Molecular Signaling 2008, 3:15 (12 September 2008)

Abstract | Full text | PDF | PubMed

16.

196
Accesses

Research article   Open Access Highly Accessed

Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor

Sharmila Shankar, Qinghe Chen, Rakesh K Srivastava Journal of Molecular Signaling 2008, 3:7 (20 March 2008)

Abstract | Full text | PDF | PubMed

17.

193
Accesses

Research article   Open Access

SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation

Thecla Constantinou, Fabrizio Baumann, Markus D Lacher, Susanne Saurer, Robert Friis, Arun Dharmarajan Journal of Molecular Signaling 2008, 3:10 (2 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

191
Accesses

Review   Open Access

The adaptor protein p62/SQSTM1 in osteoclast signaling pathways

Stephen McManus, Sophie Roux Journal of Molecular Signaling 2012, 7:1 (4 January 2012)

Abstract | Full text | PDF | PubMed

19.

184
Accesses

Review   Open Access

Consequences of nongenomic actions of estradiol on pathogenic genital tract response

Paula Solar, Luis Velasquez Journal of Molecular Signaling 2013, 8:1 (26 January 2013)

Abstract | Full text | PDF | ePUB | PubMed

20.

184
Accesses

Research article   Open Access

Estradiol effects on the dopamine transporter – protein levels, subcellular location, and function

Cheryl S Watson, Rebecca A Alyea, Bridget E Hawkins, Mary L Thomas, Kathryn A Cunningham, Adrian A Jakubas Journal of Molecular Signaling 2006, 1:5 (5 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

177
Accesses

Research article   Open Access

Multiple paxillin binding sites regulate FAK function

Danielle M Scheswohl, Jessica R Harrell, Zenon Rajfur, Guanghua Gao, Sharon L Campbell, Michael D Schaller Journal of Molecular Signaling 2008, 3:1 (2 January 2008)

Abstract | Full text | PDF | PubMed

22.

170
Accesses

Review   Open Access Highly Accessed

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression

David C New, Yung H Wong Journal of Molecular Signaling 2007, 2:2 (26 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

158
Accesses

Research article   Open Access

EGFR/Met association regulates EGFR TKI resistance in breast cancer

Kelly L Mueller, Zeng-Quan Yang, Ramsi Haddad, Stephen P Ethier, Julie L Boerner Journal of Molecular Signaling 2010, 5:8 (12 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

154
Accesses

Research article   Open Access Highly Accessed

AMPK exerts dual regulatory effects on the PI3K pathway

Rong Tao, Jun Gong, Xixi Luo, Mengwei Zang, Wen Guo, Rong Wen, Zhijun Luo Journal of Molecular Signaling 2010, 5:1 (18 February 2010)

Abstract | Full text | PDF | PubMed

25.

148
Accesses

Research article   Open Access

NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic acid differentiated SH-SY5Y Cells

Phillip H Beske, Darrell A Jackson Journal of Molecular Signaling 2012, 7:15 (8 September 2012)

Abstract | Full text | PDF | ePUB | PubMed

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