Figure 6.

Affinity/SA models of CP55244 and compound 1, 2 and 6. (A) Overlay of the Affinity/SA models of CP55244 and compound 1. (B) Key amino acid residues of the CB₁ receptor for binding with the Affinity/SA model of compound 1. H-bonding between compound 1 and the binding pocket residues is represented with white dots. (C) Overlay of the Affinity/SA model of compound 2 with compound 1. (D) Overlay of the Affinity/SA model of compound 6 with compound 1.