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Figure 5.
A working model of the role of c-FLIPS in TNFR1-mediated apoptosis. The binding of c-FLIPS to TRAF2 delays the recruitment of c-FLIPL, and c-FLIPS and c-FLIPL block TNFR1-mediated apoptosis. However, the cellular c-FLIPS level is elevated sufficiently to block apoptosis and promote cell survival.
Kim et al. Journal of Molecular Signaling 2008 3:2 doi:10.1186/1750-2187-3-2
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