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Top 10% and 20% most significant time-dependent signaling metrics as identified via PLS |
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| Cytokine |
Top 10% metrics |
Top 20% metrics (not including those in top 10%) |
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| G-CSF |
JNK lg: AUC, maximum |
JNK lg: mean, @ 30 min, derivative @ 10 min, @ 10 min |
| JNK sh: AUC |
JNK sh: derivative @ 10 min, maximum, mean, @ 30 min, @ 10 min |
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| P38: @ 30 min, @ 10 min |
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| ERK1: derivative @ 10 min |
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| ERK2: derivative @ 10 min |
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| RSK: derivative @ 10 min, @ 30 min |
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| NF-κB p65: @ 10 min, AUC, @ 30 min, maximum |
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| PKCM: derivative @ 30 min |
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| IL-1α |
JNK lg: maximum |
JNK lg: AUC, @ 30 min, mean, derivative @ 10 min, @ 10 min |
| JNK sh: AUC |
JNK sh: maximum, mean, derivative @ 10 min, @ 30 min, @ 10 min |
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| ERK1: derivative @ 10 min |
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| ERK2: derivative @ 10 min |
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| P38: @ 30 min |
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| RSK: derivative @ 10 min |
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| PKCM: derivative @ 30 min |
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| NF-κB p65: @ 10 min, AUC, maximum, @ 30 min |
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| IL-6 |
STAT3: mean, AUC, derivative @ 3 min, @ 3 min, maximum, @ 1 min, derivative @ 1 min, @ 10 min |
STAT3: @ 30 min |
| STAT1α: derivative @ 10 min |
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| STAT1β: derivative @ 10 min |
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| IL-10 |
RSK: derivative @ 10 min |
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| ERK2: derivative @ 10 min |
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| ERK1: derivative @ 10 min |
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| JNK sh: derivative @ 10 min, @ 30 min, AUC, @ 10 min |
JNKsh: maximum, mean |
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| JNK lg: @ 30 min, @ 10 min, derivative @ 10 min |
JNK lg: AUC, maximum, mean |
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| P38: derivative @ 10 min |
P38: @ 30 min |
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| NF-κB p65: AUC |
NF-κB p65: maximum, @ 30 min, @ 10 min, mean |
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| GSK3A: derivative @ 10 min |
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| MIP-1α |
JNK lg: mean, maximum, AUC |
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| NF-κB p65: @ 30 min, derivative @ 30 min |
NF-κB p65: @ 10 min |
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| JNK sh: maximum, AUC |
JNK sh: mean, derivative @ 10 min |
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| STAT5: 1 min, derivative @ 1 min |
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| ERK2: derivative @ 10 min |
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| ERK1: derivative @ 10 min |
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| PKCM: maximum, derivative @ 30 min |
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| P38 @ 30 min, maximum, @ 10 min |
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| STAT1α: derivative @ 30 min |
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| RANTES |
JNK lg: maximum, AUC, mean |
JNK lg: derivative @ 10 min, @ 30 min, @ 10 min |
| JNK sh: maximum, AUC, derivative @ 10 min |
JNK sh: mean, @ 10 min, @ 30 min |
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| ERK2: derivative @ 10 min |
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| ERK1: derivative @ 10 min |
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| RSK: derivative @ 10 min |
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| PKCM: derivative @ 30 min, maximum |
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| P38: derivative @ 10 min, @ 30 min |
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| NF-κB p65: @ 10 min |
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| TNFα |
NF-κB p65: @ 30 min, @ 10 min |
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| JNK lg: mean, maximum, AUC |
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| PKCM: derivative @ 30 min, @ 30 min, maximum |
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| P38: @ 30 min, @ 10 min, AUC |
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| JNK sh: maximum, AUC, mean |
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| RSK: @ 30 min |
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| ERK1: @ 30 min |
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| Rps6: derivative @ 30 min |
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| ERK2: @ 30 min |
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Wu et al. Journal of Molecular Signaling 2008 3:11 doi:10.1186/1750-2187-3-11 |
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