Figure 4.

Signaling network topology for RANTES based on the top ten signaling metrics. The kinases JNK and ERK1/2 were found to play an important role in regulating RANTES from the PLS analysis. Legends shown in the top row were identified directly from the data (i.e. not a model output) as the top activators of either JNK or ERK1/2. Also see Table 3.