Scaffolding proteins in G-protein signaling

doi:10.1186/1750-2187-2-13

Journal of Molecular Signaling

Volume 2

Viewing options:

Abstract
Full text
PDF (390KB)

Associated material:

Related literature:

Articles citing this article
on Google Scholar
on PubMed Central
Other articles by authors
on Google Scholar

Andreeva AV
Kutuzov MA
Voyno-Yasenetskaya TA

on PubMed

Andreeva AV
Kutuzov MA
Voyno-Yasenetskaya TA
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Review

Scaffolding proteins in G-protein signaling

Alexandra V Andreeva , Mikhail A Kutuzov and Tatyana A Voyno-Yasenetskaya

Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 909 S. Wolcott Ave, Chicago, Illinois 60612, USA

author email corresponding author email

Journal of Molecular Signaling 2007, 2:13doi:10.1186/1750-2187-2-13


Published:	30 October 2007

Abstract

Heterotrimeric G proteins are ubiquitous signaling partners of seven transmembrane-domain G-protein-coupled receptors (GPCRs), the largest (and most important pharmacologically) receptor family in mammals. A number of scaffolding proteins have been identified that regulate various facets of GPCR signaling. In this review, we summarize current knowledge concerning those scaffolding proteins that are known to directly bind heterotrimeric G proteins, and discuss the composition of the protein complexes they assemble and their effects on signal transduction. Emerging evidence about possible ways of regulation of activity of these scaffolding proteins is also discussed.