Figure 4.

Effects of curcumin on the expression of Bcl-2 family members, and inhibitors of apoptosis proteins (IAPs). (A and B), PC-3 and LNCaP cells were treated with or without curcumin (0, 5, 10 and 20 μM) for 24 or 48 h, and the expression of Bcl-2 family members (Bak, Bax, PUMA, Bim, Noxa, Bcl-X_L, Bcl-2 and Bid) was measured by the Western blot analysis. β-actin was used as a loading control. (C and D), PC-3 and LNCaP cells were treated with or without curcumin (0, 5, 10 and 20 μM) for 24 or 48 h, and the expression of IAPs (cIAP1, cIAP2, survivin and XIAP) was measured by the Western blot analysis. β-actin was used as a loading control.